BDBM534471 3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-6-chloro-N-(2,2-difluoro-3-(4-fluorophenyl)propyl)-2 -fluorobenzamide::WO2022086828, Example 207

SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)Cc2ccc(F)cc2)c1F

InChI Key InChIKey=IQUQHZXCHBDAAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 534471   

TargetMixed lineage kinase domain-like protein(Human)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534471(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 1.80nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534471(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 0.600nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828