BDBM534452 WO2022086828, Example 188

SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@@H](O)c2cc(F)cc(F)c2)c1F

InChI Key InChIKey=WXNOXFAWDUEBAQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 534452   

TargetMixed lineage kinase domain-like protein(Human)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534452(WO2022086828, Example 188)
Affinity DataIC50: 6.30nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534452(WO2022086828, Example 188)
Affinity DataIC50: 0.300nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

LigandPNGBDBM534452(WO2022086828, Example 188)
Affinity DataIC50: 9.40E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 40 nM probe and 1 nM GST-tagged PIK3C5 in complex with PIK3R1 (Invitrogen #...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828