BDBM534410 (S)-5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-N-(3-(4-chlorophenyl)-3-hydroxypropyl)-2,4-dimethylbenzamide::WO2018148626, Example 146::WO2022086828, Example 146

SMILES Cc1cc(C)c(cc1C(=O)NCC[C@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1

InChI Key InChIKey=VDFIPIOXCKVOHD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 534410   

TargetMixed lineage kinase domain-like protein(Human)
Bristol Myers Squibb

WIPO
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 0.600nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 0.600nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 2.40nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMixed lineage kinase domain-like protein(Human)
Bristol Myers Squibb

WIPO
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 2.40nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 1.50E+4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 40 nM probe and 1 nM GST-tagged PIK3C5 in complex with PIK3R1 (Invitrogen #...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828