BDBM533495 (2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimidin-7-yl)-5-(1-(4- chlorophenyl)ethyl)tetrahydrofuran-3,4- diol::US11220524, Example 5-C::US11220524, Example 6-C

SMILES CC([C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)c1ccc(Cl)cc1

InChI Key InChIKey=BVCRIZZSQGCZCK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 533495   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM533495((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 37nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM533495((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 6.90nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
Go to US Patent