BDBM5327 2-quinolinone deriv. 2::3-(1H-1,3-benzodiazol-2-yl)-1,2-dihydroquinolin-2-one::CHEMBL118440

SMILES O=c1[nH]c2ccccc2cc1-c1nc2ccccc2[nH]1

InChI Key InChIKey=CMHODBMVRLRLOW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5327   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5327(CHEMBL118440 | 3-(1H-1,3-benzodiazol-2-yl)-1,2-dih...)
Affinity DataIC50: 45nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM5327(CHEMBL118440 | 3-(1H-1,3-benzodiazol-2-yl)-1,2-dih...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM5327(CHEMBL118440 | 3-(1H-1,3-benzodiazol-2-yl)-1,2-dih...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5327(CHEMBL118440 | 3-(1H-1,3-benzodiazol-2-yl)-1,2-dih...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed