BDBM532173 US11208422, Example 21::US11208422, Example 32

SMILES COc1cccc(n1)C(=O)N1CCC2CCC1CN2Cc1c(nc2ncccn12)-c1ccc(Cl)cc1

InChI Key InChIKey=AOLFRRHHULQGIB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 532173   

TargetPotassium channel subfamily K member 3(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM532173(US11208422, Example 32 | US11208422, Example 21)
Affinity DataIC50: 1.80E+4nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetPotassium channel subfamily K member 9(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM532173(US11208422, Example 32 | US11208422, Example 21)
Affinity DataIC50: 140nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetPotassium channel subfamily K member 3(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM532173(US11208422, Example 32 | US11208422, Example 21)
Affinity DataIC50: 130nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetPotassium channel subfamily K member 9(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM532173(US11208422, Example 32 | US11208422, Example 21)
Affinity DataIC50: 4.10nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent