BDBM532023 N-(6-[2-Amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl] pyridazin-3-yl}-5-(4-methylphenyl)-4-oxo-1-(tetrahydro-2H-pyran-4-ylmethyl)-1,4-dihydropyridine-3-carboxamide::US11208403, Example 100

SMILES COc1ccc(cc1OC)-c1cnc(N)c(c1)-c1ccc(NC(=O)c2cn(CC3CCOCC3)cc(-c3ccc(C)cc3)c2=O)nn1

InChI Key InChIKey=IIOBIZXRVAIIAJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 532023   

TargetTyrosine-protein kinase receptor UFO(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM532023(N-(6-[2-Amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]...)
Affinity DataIC50: 0.300nMAssay Description:A kinase dilution solution containing 170 ng/ml AXL (the 464th to 885th amino acids of the intracellular domain of human AXL expressed as a fusion pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM532023(N-(6-[2-Amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]...)
Affinity DataIC50: 6nMAssay Description:A phosphorylated Axl (hereinafter, referred to as pAxl) inhibition test was conducted using a human non-small cell lung cancer-derived cell line NCI-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM532023(N-(6-[2-Amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]...)
Affinity DataIC50: 1.57E+3nMAssay Description:A kinase dilution solution containing 20 ng/ml Mer (the 528th to 999th amino acids of the intracellular domain of human MER expressed as a fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
US Patent