BDBM531674 N-{1-(cyclopropylmethyl)-4-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-6-[5-(difluoromethyl)-3-methyl-1H-pyrazol-1-yl]pyrimidin-4-amine::US11208400, Example 307

SMILES O=c1c(N(Cc2ncc(-c3nnc(C(F)F)o3)cc2F)c2ccccc2)c(N2C[C@@H]3C[C@H]2CN3C2COC2)c1=O

InChI Key InChIKey=CYUYHLDIXXEZLS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531674   

TargetHistone deacetylase 6(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 531674BDBM531674(Synthesis of 3-(((5-(5-(difluoromethyl)-1,3,4-oxad...)
Affinity DataIC50: 54nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent

TargetHistone deacetylase 1(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 531674BDBM531674(Synthesis of 3-(((5-(5-(difluoromethyl)-1,3,4-oxad...)
Affinity DataIC50: 1.00E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent