BDBM531069 (R)-4-(4-(1H-imidazol-2-yl)piperidin-1-yl)-N1-(3-amino-2-hydroxy propyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US11207312, Example 201

SMILES NC[C@@H](O)CNS(=O)(=O)c1ccc(N2CCC(CC2)c2ncc[nH]2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=HLOVJTXLVHNCDN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 531069   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531069(US11207312, Example 201 | (R)-4-(4-(1H-imidazol-2-...)
Affinity DataIC50: 1.83nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531069(US11207312, Example 201 | (R)-4-(4-(1H-imidazol-2-...)
Affinity DataIC50: 0.770nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531069(US11207312, Example 201 | (R)-4-(4-(1H-imidazol-2-...)
Affinity DataIC50: 0.260nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531069(US11207312, Example 201 | (R)-4-(4-(1H-imidazol-2-...)
Affinity DataIC50: 0.640nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent