BDBM531045 N1-((R)-3-amino-2- hydroxypropyl)-4-(4-(2- oxooxazolidin-4-yl)piperidin- 1-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US11207312, Example 177

SMILES NC[C@@H](O)CNS(=O)(=O)c1ccc(N2CCC(CC2)C2COC(=O)N2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=AADKYZQKXNREKK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 531045   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531045(US11207312, Example 177 | N1-((R)-3-amino-2- hydro...)
Affinity DataIC50: 0.570nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531045(US11207312, Example 177 | N1-((R)-3-amino-2- hydro...)
Affinity DataIC50: 0.190nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531045(US11207312, Example 177 | N1-((R)-3-amino-2- hydro...)
Affinity DataIC50: 0.150nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531045(US11207312, Example 177 | N1-((R)-3-amino-2- hydro...)
Affinity DataIC50: 0.660nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent