BDBM530975 4-[3- (hydroxymethyl)piperidin-1- yl]-N1-[(3R)-pyrrolidin-3-yl]- 3-(1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US11207312, Example 107

SMILES NS(=O)(=O)c1c(ccc(N2CCCC(CO)C2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1

InChI Key InChIKey=QDRNELLVCKPVOG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530975   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530975(US11207312, Example 107 | 4-[3- (hydroxymethyl)pip...)
Affinity DataIC50: 0.25nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530975(US11207312, Example 107 | 4-[3- (hydroxymethyl)pip...)
Affinity DataIC50: 1.10nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530975(US11207312, Example 107 | 4-[3- (hydroxymethyl)pip...)
Affinity DataIC50: 0.190nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530975(US11207312, Example 107 | 4-[3- (hydroxymethyl)pip...)
Affinity DataIC50: 0.420nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent