BDBM530969 4-[4- (hydroxymethyl)piperidin- 1-yl]-N1-[(3R)-pyrrolidin-3- yl]-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US11207312, Example 101

SMILES NS(=O)(=O)c1c(ccc(N2CCC(CO)CC2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1

InChI Key InChIKey=CAYHAEYZSNEDCI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530969   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530969(US11207312, Example 101 | 4-[4- (hydroxymethyl)pip...)
Affinity DataIC50: 0.0800nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530969(US11207312, Example 101 | 4-[4- (hydroxymethyl)pip...)
Affinity DataIC50: 0.160nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530969(US11207312, Example 101 | 4-[4- (hydroxymethyl)pip...)
Affinity DataIC50: 0.0900nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530969(US11207312, Example 101 | 4-[4- (hydroxymethyl)pip...)
Affinity DataIC50: 0.390nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent