BDBM530931 4-(4-hydroxypiperidin-1- yl)-N1-[(3R)-pyrrolidin-3- yl]-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US11207312, Example 63

SMILES NS(=O)(=O)c1c(ccc(N2CCC(O)CC2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1

InChI Key InChIKey=NSEYRXDYYZWBRO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530931   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530931(US11207312, Example 63 | 4-(4-hydroxypiperidin-1- ...)
Affinity DataIC50: 0.310nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530931(US11207312, Example 63 | 4-(4-hydroxypiperidin-1- ...)
Affinity DataIC50: 0.470nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530931(US11207312, Example 63 | 4-(4-hydroxypiperidin-1- ...)
Affinity DataIC50: 0.160nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530931(US11207312, Example 63 | 4-(4-hydroxypiperidin-1- ...)
Affinity DataIC50: 0.660nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent