BDBM530893 (R)-2-(1-(4-(N-(3-amino- 2- hydroxypropyl)sulfamoyl)- 3-sulfamoyl-2-(2H- tetrazol-5- yl)phenyl)piperidin-4- yl)acetamide::US11207312, Example 25

SMILES NC[C@@H](O)CNS(=O)(=O)c1ccc(N2CCC(CC(N)=O)CC2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=IZRGISIZXAAYTN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530893   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530893(US11207312, Example 25 | (R)-2-(1-(4-(N-(3-amino- ...)
Affinity DataIC50: 0.540nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530893(US11207312, Example 25 | (R)-2-(1-(4-(N-(3-amino- ...)
Affinity DataIC50: 0.390nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530893(US11207312, Example 25 | (R)-2-(1-(4-(N-(3-amino- ...)
Affinity DataIC50: 0.170nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530893(US11207312, Example 25 | (R)-2-(1-(4-(N-(3-amino- ...)
Affinity DataIC50: 0.740nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent