BDBM530890 (R)-N1-(3-amino-2- hydroxypropyl)-4-(4- fluoro-4- (hydroxymethyl)piperidin- 1-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US11207312, Example 22

SMILES NC[C@@H](O)CNS(=O)(=O)c1ccc(N2CCC(F)(CO)CC2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=FQFYCZPTOXFNDS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530890   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530890(US11207312, Example 22 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 0.450nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530890(US11207312, Example 22 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 0.700nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530890(US11207312, Example 22 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 0.350nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530890(US11207312, Example 22 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 0.790nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent