BDBM529784 US11203594, Example 2::WO2020212865, Example 2

SMILES CC(=O)c1c(C)c2cnc(N[C@@H]3CCOC[C@H]3O)nc2n(C2CCCC2)c1=O

InChI Key InChIKey=YVGUVHSVOMWPCR-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 529784   

LigandPNGBDBM529784(US11203594, Example 2 | WO2020212865, Example 2)
Affinity DataIC50: 8.80nMAssay Description:Compounds disclosed herein were tested for inhibition of CDK4/Cyclin D1 or CDK6/Cyclin D3 kinase in an assay based on the time-resolved fluorescence-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM529784(US11203594, Example 2 | WO2020212865, Example 2)
Affinity DataIC50: 37nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM529784(US11203594, Example 2 | WO2020212865, Example 2)
Affinity DataKi:  0.800nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent

LigandPNGBDBM529784(US11203594, Example 2 | WO2020212865, Example 2)
Affinity DataKi:  1.20nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent