BDBM529585 (R)-1-(aziridin-1-ylsulfonyl)-N—((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)pyrrolidine-3-carboxamide::US11203586, Example 36

SMILES Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCN(C1)S(=O)(=O)N1CC1

InChI Key InChIKey=JFDWYGBPFNMWTQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 529585   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM529585((R)-1-(aziridin-1-ylsulfonyl)-N—((S)-1-(2-chl...)
Affinity DataIC50: 20nMAssay Description:The specific operation was as follows: 2.5 μl of the compound diluted in a 3-fold gradient was added to a 384-well plate, followed by adding 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
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