BDBM5291 2-[(4-{[4-(2-hydroxyacetyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1,3-thiazole-5-carbonitrile::2-{4-[4-(2-Hydroxyethanoyl)piperazin-1-ylmethyl]pyridin-2-ylamino}thiazole-5-carbonitrile::N-(1,3-Thiazol-2-yl)pyridin-2-amine 21

SMILES OCC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1

InChI Key InChIKey=WUAWDHDGRGQQSS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5291   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5291(2-{4-[4-(2-Hydroxyethanoyl)piperazin-1-ylmethyl]py...)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2005
Entry Details Article
PubMed