BDBM528355 9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-2-methylpyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 13

SMILES CCCCn1c2ccc(C)nc2n2c(nnc2c1=O)C1(CC1)C1CC1

InChI Key InChIKey=OZQQLPFSQLZXQT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 528355   

LigandPNGBDBM528355(US11180503, Example 13 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 0.816nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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LigandPNGBDBM528355(US11180503, Example 13 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 3nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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LigandPNGBDBM528355(US11180503, Example 13 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 1.13nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Eli Lilly

US Patent
LigandPNGBDBM528355(US11180503, Example 13 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 1.92E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Eli Lilly

US Patent
LigandPNGBDBM528355(US11180503, Example 13 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 2.09E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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LigandPNGBDBM528355(US11180503, Example 13 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 2.99E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent