BDBM528348 5-butyl-3-methyl-9-(1-methylcyclopropyl)pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 6

SMILES CCCCn1c2cc(C)cnc2n2c(nnc2c1=O)C1(C)CC1

InChI Key InChIKey=OBFZSUOIZKEKHN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 528348   

LigandPNGBDBM528348(US11180503, Example 6 | 5-butyl-3-methyl-9-(1-meth...)
Affinity DataIC50: 11.6nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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LigandPNGBDBM528348(US11180503, Example 6 | 5-butyl-3-methyl-9-(1-meth...)
Affinity DataIC50: 2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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LigandPNGBDBM528348(US11180503, Example 6 | 5-butyl-3-methyl-9-(1-meth...)
Affinity DataIC50: 15.4nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Eli Lilly

US Patent
LigandPNGBDBM528348(US11180503, Example 6 | 5-butyl-3-methyl-9-(1-meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Eli Lilly

US Patent
LigandPNGBDBM528348(US11180503, Example 6 | 5-butyl-3-methyl-9-(1-meth...)
Affinity DataIC50: 6.01E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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LigandPNGBDBM528348(US11180503, Example 6 | 5-butyl-3-methyl-9-(1-meth...)
Affinity DataIC50: 9.59E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent