BDBM528020 US11180482, Example I-2

SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1

InChI Key InChIKey=QWCVGHXDHVKGAQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 528020   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528020(US11180482, Example I-2)
Affinity DataIC50: 5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528020(US11180482, Example I-2)
Affinity DataIC50: 5nMAssay Description:Inhibition of HPK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528020(US11180482, Example I-2)
Affinity DataIC50: 0.334nMAssay Description:Inhibition of N-terminal DYKDDDDK-tagged human HPK1 (1 to 346 residues) expressed in baculovirus expression system using SLP76 as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528020(US11180482, Example I-2)
Affinity DataIC50: 100nMAssay Description:Inhibition of HPK1 in human PBMC assessed as inhibition of SLP76 phosphorylation incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM528020(US11180482, Example I-2)
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type HPK1 (unknown origin) using FAM-FPQAAsLPPYFAKKK peptide as substrate in presence of ATP by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed