BDBM527928 (S)-1'-(8-((2-amino- 3-chloropyridin-4- yl)thio)imidazo[1,2- c]pyrimidin-5-yl)- 5,7- dihydrospiro [cyclopenta[b] pyridine-6,4'- piperidin]-5-amine::US11179397, Example 147

SMILES N[C@@H]1c2cccnc2CC11CCN(CC1)c1ncc(Sc2ccnc(N)c2Cl)c2nccn12

InChI Key InChIKey=PQNDHWFSXFZDJE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527928   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527928((S)-1'-(8-((2-amino- 3-chloropyridin-4- yl)thio)im...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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