BDBM527927 (S)-1'-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]pyrimidin-5-yl)- 5,7- dihydrospiro [cyclopenta[b] pyridine-6,4'- piperidin]-5-amine::US11179397, Example 146

SMILES N[C@@H]1c2cccnc2CC11CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)c2nccn12

InChI Key InChIKey=JVKMRWOADDUHNG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527927   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527927((S)-1'-(8-((2,3- dichlorophenyl)thio) imidazo[1,2-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent