BDBM527922 (S)-1'-(8-((2- (methylthio)phenyl) thio)imidazo[1,2- c]pyrimidin-5-yl)- 1,3- dihydrospiro[indene- 2,4'-piperidin]-1- amine::US11179397, Example 141

SMILES CSc1ccccc1Sc1cnc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)n2ccnc12

InChI Key InChIKey=FODXINMUBAXBFW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527922   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527922((S)-1'-(8-((2- (methylthio)phenyl) thio)imidazo[1,...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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