BDBM527921 (S)-1'-(8- (benzo[d]isothiazol- 7-ylthio) imidazo[1,2-c] pyrimidin-5- yl)-1,3- dihydrospiro [indene-2,4'- piperidin]-1- amine::US11179397, Example 140

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1ncc(Sc2cccc3cnsc23)c2nccn12

InChI Key InChIKey=MSFASVHYEUXLEG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527921   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527921((S)-1'-(8- (benzo[d]isothiazol- 7-ylthio) imidazo[...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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