BDBM527919 (S)-1'-(8-(thieno[2,3- b]pyridin-4- ylthio)imidazo[1,2-c] pyrimidin-5-yl)-1,3- dihydrospiro[indene- 2,4'-piperidin]-1- amine::US11179397, Example 138

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1ncc(Sc2ccnc3sccc23)c2nccn12

InChI Key InChIKey=NAOWROHXHZTLSX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527919   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527919((S)-1'-(8-(thieno[2,3- b]pyridin-4- ylthio)imidazo...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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