BDBM527917 (S)-1'-(8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)- 1,3- dihydrospiro[indene- 2,4'-piperidin]-1- amine::US11179397, Example 135

SMILES Cc1nc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)n2ccnc2c1-c1cccc(Cl)c1Cl

InChI Key InChIKey=SMRYEETZZZKCJT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527917   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527917((S)-1'-(8-(2,3- dichlorophenyl)-7- methylimidazo[1...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent