BDBM527897 (3S,4S)-3- methyl-8-(8- (quinolin-4- ylthio)imidazo [1,2-c]pyrimidin- 5-yl)-2-oxa-8- azaspiro[4.5] decan-4-amine::US11179397, Example 114

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4ccccc34)c3nccn23)[C@@H]1N

InChI Key InChIKey=IZNPQEUSRISJHW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527897   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527897((3S,4S)-3- methyl-8-(8- (quinolin-4- ylthio)imidaz...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent