BDBM527864 (R)-8-(8-((2-chloro-3- methylpyridin-4- yl)thio)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan-1- amine::US11179397, Example 81

SMILES Cc1c(Cl)nccc1Sc1cnc(N2CCC3(CCC[C@H]3N)CC2)n2ccnc12

InChI Key InChIKey=ZSOKXJAZKRZARB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527864   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527864((R)-8-(8-((2-chloro-3- methylpyridin-4- yl)thio)im...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2022
Entry Details
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