BDBM527861 (R)-8-(8-(quinolin- 4- ylthio)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine::US11179397, Example 78::US11498930, Compound 1.1.46

SMILES N[C@@H]1CCCC11CCN(CC1)c1ncc(Sc2ccnc3ccccc23)c2nccn12

InChI Key InChIKey=TYFYPIKZKUQFCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 527861   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527861((R)-8-(8-(quinolin- 4- ylthio)imidazo[1,2- c]pyrim...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527861((R)-8-(8-(quinolin- 4- ylthio)imidazo[1,2- c]pyrim...)
Affinity DataIC50: 100nMAssay Description:Compound powders were dissolved in DMSO to prepare mother liquor.During the experiment, the stock solutions of the compounds were subjected to 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
Go to US Patent