BDBM527858 (2R,4R)-4-amino-8- (8-((2,3- dichlorophenyl)thio)- 7-methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 2-ol::US11179397, Example 75

SMILES Cc1nc(N2CCC3(C[C@@H](O)C[C@H]3N)CC2)n2ccnc2c1Sc1cccc(Cl)c1Cl

InChI Key InChIKey=WYORRSROTONLKF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527858   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527858((2R,4R)-4-amino-8- (8-((2,3- dichlorophenyl)thio)-...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent