BDBM527850 (3S,4S)-8-(8-(2,3- dichlorophenyl)-7- methyl- [1,2,4]triazolo[4,3- c]pyrimidin-5-yl)-3- methyl-2-oxa-8- azaspiro[4.5]decan- 4-amine::US11179397, Example 67::US11673901, Compound 6

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(-c3cccc(Cl)c3Cl)c3nncn23)[C@@H]1N

InChI Key InChIKey=QJGBOYULUBNPMW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 527850   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527850((3S,4S)-8-(8-(2,3- dichlorophenyl)-7- methyl- [1,2...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527850((3S,4S)-8-(8-(2,3- dichlorophenyl)-7- methyl- [1,2...)
Affinity DataIC50: 10nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.00005-10 μM) was monitored using an assay in which 0.2 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527850((3S,4S)-8-(8-(2,3- dichlorophenyl)-7- methyl- [1,2...)
Affinity DataIC50: 50nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.00005-10 μM) was monitored using an assay in which 0.2 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent