BDBM527838 (3S,4S)-8-(8- ((2,3- dichlorophenyl) thio)imidazo[1,2- c]pyrimidin-5-yl)- 3-methyl-2-oxa- 8- azaspiro[4.5]decan- 4-amine::US11179397, Example 55::US11498930, Compound 1.1.15::US11673901, Compound 11

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3cccc(Cl)c3Cl)c3nccn23)[C@@H]1N

InChI Key InChIKey=UBMGNSFEVNTZIP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 527838   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527838((3S,4S)-8-(8- ((2,3- dichlorophenyl) thio)imidazo[...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527838((3S,4S)-8-(8- ((2,3- dichlorophenyl) thio)imidazo[...)
Affinity DataIC50: 100nMAssay Description:Compound powders were dissolved in DMSO to prepare mother liquor.During the experiment, the stock solutions of the compounds were subjected to 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527838((3S,4S)-8-(8- ((2,3- dichlorophenyl) thio)imidazo[...)
Affinity DataIC50: 50nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.00005-10 μM) was monitored using an assay in which 0.2 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent