BDBM527818 (2R,4R)-4-amino-8- (8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 2-ol::US11179397, Example 35

SMILES N[C@@H]1C[C@H](O)CC11CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)c2nccn12

InChI Key InChIKey=BVIQSDHAXALDIN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527818   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527818((2R,4R)-4-amino-8- (8-((2,3- dichlorophenyl)thio) ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent