BDBM527770 3-(1-methyl-1H-pyrazol-4- yl)-5-(2-oxo-1-propyl-3-oxa- 1,8-diazaspiro[4.5]dec-8- yl)pyrazine-2-carbonitrile::US11179389, Compound 1-22

SMILES CCCN1C(=O)OCC11CCN(CC1)c1cnc(C#N)c(n1)-c1cnn(C)c1

InChI Key InChIKey=ARSZMVVBCANYRZ-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527770   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM527770(3-(1-methyl-1H-pyrazol-4- yl)-5-(2-oxo-1-propyl-3-...)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/10/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL