BDBM527769 3-(1-methyl-1H-pyrazol-4- yl)-5-[2-oxo-1-(2,2,2- trifluoroethyl)-1,8- diazaspiro[4.5]dec-8- yl]pyrazine-2-carbonitrile::US11179389, Compound 1-21

SMILES Cn1cc(cn1)-c1nc(cnc1C#N)N1CCC2(CCC(=O)N2CC(F)(F)F)CC1

InChI Key InChIKey=KZWZOCFRAFVSHS-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527769   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM527769(3-(1-methyl-1H-pyrazol-4- yl)-5-[2-oxo-1-(2,2,2- t...)Copy SMILESCopy InChI

Affinity DataIC50: 37nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/10/2022
Entry Details
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