BDBM527637 US11186589, Compound 9::US11186589, Compound 9c

SMILES CC(=O)N1CCc2c1c(Cl)cc(Nc1nccc(n1)-c1cc3c(NCC3(C)CO)c(c1)C#N)c2C

InChI Key InChIKey=WCICBNWTEXOUQI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 527637   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM527637(US11186589, Compound 9c | US11186589, Compound 9)
Affinity DataIC50: 2nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (αscreen) format (Perkin Elmer). All compounds tested were dissolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM527637(US11186589, Compound 9c | US11186589, Compound 9)
Affinity DataIC50: 10.5nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (αscreen) format (Perkin Elmer). All compounds tested were dissolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent