BDBM526544 1-acryloyl-N-(3-(((2-(((3S,4S)-3-fluoropiperidin-4-yl)amino)-8-isopropyl pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)methyl)phenyl)pyrrolidine-3- carboxamide::US11186576, Compound 14.

SMILES CC(C)c1cnn2c(NCc3cccc(NC(=O)C4CCN(C4)C(=O)C=C)c3)nc(N[C@@H]3CCNC[C@H]3F)nc12

InChI Key InChIKey=KGHZKXNQBOKOPW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526544   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM526544(1-acryloyl-N-(3-(((2-(((3S,4S)-3-fluoropiperidin-4...)
Affinity DataIC50: 300nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent