BDBM526323 US11186544, Example 258

SMILES Cc1cnc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2F)-c2ccccc2NS(C)(=O)=O)cn1

InChI Key InChIKey=LPEZWOPFRXAYNB-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 526323   

TargetN-formyl peptide receptor 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM526323(US11186544, Example 258)
Affinity DataEC50:  20nMAssay Description:A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetN-formyl peptide receptor 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM526323(US11186544, Example 258)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetfMet-Leu-Phe receptor(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM526323(US11186544, Example 258)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetfMet-Leu-Phe receptor(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM526323(US11186544, Example 258)
Affinity DataEC50: >1.00E+4nMAssay Description:A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent