BDBM526227 5-chloro-2-fluoro-4-(((6-fluoro-1H-indazol-7-yl)methyl)amino)-N-(thiazol-4-yl)benzenesulfonamide formate::US11174268, Example 334

SMILES Fc1ccc2cn[nH]c2c1CNc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=VVQNYDYIEOFQKO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 526227   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526227(5-chloro-2-fluoro-4-(((6-fluoro-1H-indazol-7-yl)me...)
Affinity DataIC50: 29nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526227(5-chloro-2-fluoro-4-(((6-fluoro-1H-indazol-7-yl)me...)
Affinity DataIC50: 2nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526227(5-chloro-2-fluoro-4-(((6-fluoro-1H-indazol-7-yl)me...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526227(5-chloro-2-fluoro-4-(((6-fluoro-1H-indazol-7-yl)me...)
Affinity DataIC50: 4.65E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent