BDBM526168 (S)-4-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-2-fluoro-5-methyl-N-(pyrimidin-4-yl)benzenesulfonamide::US11174268, Example 275

SMILES C[C@H](Nc1cc(F)c(cc1C)S(=O)(=O)Nc1ccncn1)c1cc(Cl)ccc1F

InChI Key InChIKey=MMDJKBKDDVNRLB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 526168   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526168((S)-4-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-2-...)
Affinity DataIC50: 174nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526168((S)-4-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-2-...)
Affinity DataIC50: 25nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526168((S)-4-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-2-...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526168((S)-4-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-2-...)
Affinity DataIC50: 5.33E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526168((S)-4-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-2-...)
Affinity DataIC50: 4.85E+3nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent