BDBM526163 (R)-5-chloro-4-((1-(5-chloro-2-fluorophenyl)-2,2,2-trifluoroethyl)amino)-2-fluoro-N-(pyrimidin-4-yl)benzenesulfonamide::US11174268, Example 270

SMILES Fc1ccc(Cl)cc1[C@@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)C(F)(F)F

InChI Key InChIKey=CJFBPYGVRWIWOB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 526163   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526163((R)-5-chloro-4-((1-(5-chloro-2-fluorophenyl)-2,2,2...)
Affinity DataIC50: 213nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526163((R)-5-chloro-4-((1-(5-chloro-2-fluorophenyl)-2,2,2...)
Affinity DataIC50: 18nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526163((R)-5-chloro-4-((1-(5-chloro-2-fluorophenyl)-2,2,2...)
Affinity DataIC50: 1.10E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526163((R)-5-chloro-4-((1-(5-chloro-2-fluorophenyl)-2,2,2...)
Affinity DataIC50: 1.25E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526163((R)-5-chloro-4-((1-(5-chloro-2-fluorophenyl)-2,2,2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent