BDBM526158 (S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-((1-phenylpropyl)amino)benzenesulfonamide::US11174268, Example 265

SMILES CC[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)s1)c1ccccc1

InChI Key InChIKey=TXAYOTYZKGQCMM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 526158   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526158((S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-(...)
Affinity DataIC50: 194nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526158((S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-(...)
Affinity DataIC50: 18nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526158((S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-(...)
Affinity DataIC50: 1.25E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526158((S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-(...)
Affinity DataIC50: 794nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526158((S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-(...)
Affinity DataIC50: 50nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent