BDBM526108 4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)amino)-2,3,6-trifluoro-N-(thiazol-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US11174268, Example 215

SMILES Fc1ccc(F)c(CN2CCC2)c1CNc1cc(F)c(c(F)c1F)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=GVGXSDKGWUEOAT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 526108   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526108(4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)ami...)
Affinity DataIC50: 21nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526108(4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)ami...)
Affinity DataIC50: 3nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526108(4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)ami...)
Affinity DataIC50: 2.15E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526108(4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)ami...)
Affinity DataIC50: 1.03E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent