BDBM526090 4-((2-(azetidin-1-ylmethyl)-3-fluorobenzyl)amino)-3-chloro-2,6-difluoro-N-(thiazol-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US11174268, Example 197

SMILES Fc1cccc(CNc2cc(F)c(c(F)c2Cl)S(=O)(=O)Nc2cscn2)c1CN1CCC1

InChI Key InChIKey=NNPVGJOKZSHCDG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 526090   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526090(4-((2-(azetidin-1-ylmethyl)-3-fluorobenzyl)amino)-...)
Affinity DataIC50: 23nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526090(4-((2-(azetidin-1-ylmethyl)-3-fluorobenzyl)amino)-...)
Affinity DataIC50: 2.76E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526090(4-((2-(azetidin-1-ylmethyl)-3-fluorobenzyl)amino)-...)
Affinity DataIC50: 1.20E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent