BDBM526079 4-((2-((5-azaspiro[2.3]hexan-5-yl)methyl)-6-fluorobenzyl)amino)-2,6-difluoro-N-(thiazol-4-yl)benzenesulfonamide formate::US11174268, Example 186

SMILES Fc1cccc(CN2CC3(CC3)C2)c1CNc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=SRUVSSHMTBEYEQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 526079   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526079(4-((2-((5-azaspiro[2.3]hexan-5-yl)methyl)-6-fluoro...)
Affinity DataIC50: 19nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526079(4-((2-((5-azaspiro[2.3]hexan-5-yl)methyl)-6-fluoro...)
Affinity DataIC50: 9.12E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526079(4-((2-((5-azaspiro[2.3]hexan-5-yl)methyl)-6-fluoro...)
Affinity DataIC50: 1.55E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent