BDBM526065 2,6-difluoro-4-((2-fluoro-6-((3-methoxy-3-methylazetidin-1-yl)methyl)benzyl)amino)-N-(thiazol-4-yl)benzenesulfonamide ::US11174268, Example 172

SMILES COC1(C)CN(Cc2cccc(F)c2CNc2cc(F)c(c(F)c2)S(=O)(=O)Nc2cscn2)C1

InChI Key InChIKey=QKWMGDPIHZORDH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 526065   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526065(2,6-difluoro-4-((2-fluoro-6-((3-methoxy-3-methylaz...)
Affinity DataIC50: 78nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526065(2,6-difluoro-4-((2-fluoro-6-((3-methoxy-3-methylaz...)
Affinity DataIC50: 23nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526065(2,6-difluoro-4-((2-fluoro-6-((3-methoxy-3-methylaz...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526065(2,6-difluoro-4-((2-fluoro-6-((3-methoxy-3-methylaz...)
Affinity DataIC50: 2.58E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent