BDBM526062 2,6-difluoro-4-((2-fluoro-6-((3-hydroxy-3-methylazetidin-1-yl)methyl)benzyl)amino)-N- (thiazol-4-yl)benzenesulfonamide::US11174268, Example 169::US11174268, Example 170

SMILES CC1(O)CN(Cc2cccc(F)c2CNc2cc(F)c(c(F)c2)S(=O)(=O)Nc2cscn2)C1

InChI Key InChIKey=UBGLOSUAFLCIGE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 526062   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526062(US11174268, Example 169 | 2,6-difluoro-4-((2-fluor...)
Affinity DataIC50: 11nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526062(US11174268, Example 169 | 2,6-difluoro-4-((2-fluor...)
Affinity DataIC50: 2.90E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526062(US11174268, Example 169 | 2,6-difluoro-4-((2-fluor...)
Affinity DataIC50: 6.38E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526062(US11174268, Example 169 | 2,6-difluoro-4-((2-fluor...)
Affinity DataIC50: 176nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526062(US11174268, Example 169 | 2,6-difluoro-4-((2-fluor...)
Affinity DataIC50: 1.52E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526062(US11174268, Example 169 | 2,6-difluoro-4-((2-fluor...)
Affinity DataIC50: 2.47E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent