BDBM526059 2,6-difluoro-4-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino)-N-(thiazol-4-yl)benzenesulfonamide::US11174268, Example 166

SMILES Fc1cccc(CN2CCCC2)c1CNc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=KDWRZRJLRMOYNS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 526059   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526059(2,6-difluoro-4-((2-fluoro-6-(pyrrolidin-1-ylmethyl...)
Affinity DataIC50: 15nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526059(2,6-difluoro-4-((2-fluoro-6-(pyrrolidin-1-ylmethyl...)
Affinity DataIC50: 1.52E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM526059(2,6-difluoro-4-((2-fluoro-6-(pyrrolidin-1-ylmethyl...)
Affinity DataIC50: 1.27E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent