BDBM525998 5-chloro-2-fluoro-4-((1-phenylcyclobutyl)amino)-N-(thiazol-2-yl)benzenesulfonamide::US11174268, Example 105

SMILES Fc1cc(NC2(CCC2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=BQOJERULLMOGNQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 525998   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525998(5-chloro-2-fluoro-4-((1-phenylcyclobutyl)amino)-N-...)
Affinity DataIC50: 564nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525998(5-chloro-2-fluoro-4-((1-phenylcyclobutyl)amino)-N-...)
Affinity DataIC50: 27nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525998(5-chloro-2-fluoro-4-((1-phenylcyclobutyl)amino)-N-...)
Affinity DataIC50: 1.06E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525998(5-chloro-2-fluoro-4-((1-phenylcyclobutyl)amino)-N-...)
Affinity DataIC50: 3.73E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525998(5-chloro-2-fluoro-4-((1-phenylcyclobutyl)amino)-N-...)
Affinity DataIC50: 3.60E+3nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent